Literature summary extracted from

Jin, J.K.; Jang, B.; Jin, H.T.; Choi, E.K.; Jung, C.G.; Akatsu, H.; Kim, J.I.; Carp, R.I.; Kim, Y.S.
Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease (2015), PLoS ONE, 10, e0122120 .

Application

EC Number	Application	Comment	Organism
3.1.4.50	medicine	the expression of GPI-PLD is dramatically down-regulated in both the brain and cerebrospinal fluids of Creutzfeldt-Jakob disease patients, while no differences in expression are observed in either the brains or cerebrospinal fluids specimens from Alzheimer's disease patients	Homo sapiens
3.1.4.50	medicine	the expression of GPI-PLD is dramatically down-regulated in the brains of scrapie-infected mice, especially in the caveolin-enriched membrane fractions. The decrease in GPI-PLD expression levels begins at the same time that prion proteins begin to accumulate in the infected brains	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.50	Homo sapiens	P80108	-	-
3.1.4.50	Mus musculus	O70362	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.4.50	brain	-	Mus musculus	-
3.1.4.50	brain	-	Homo sapiens	-

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Release 2023.1 (January 2023)